acne medication and cancer    


acne medication and cancer

What is acne?

Acne, a chronic inflammatory disease of the pilosebaceous units of the face, neck, chest, and back, is the most common skin disorder occurring universally, with an estimated prevalence of 70-87%(1) It is a pleomorphic disorder characterized by both inflammatory (papules, pustules, nodules) and noninflammatory (comedones, open and closed) lesions Grading of acne is mandatory to determine the appropriate therapeutic strategy Mild acne can be purely comedonal or mild papulopustular, with a few papulopustules present as well(2) Moderate acne is characterized by numerous comedones, few to many pustules, and few small nodules, with no residual scarring(2) In severe acne papulopustules are numerous, many nodules can be detected, inflammation is marked, and scarring is present(2) Very severe acne can be recognized by sinus tracts, grouped comedones, many deeply located nodules, and severe inflammation and scarring(2) Although acne does not affect health overall, its impact on emotional well-being and function can be 
                                                                                  
Open comedo: A blackhead) a noninflammatory comedo with a dark top and firmly packed contents                                                                                     

Vitamin C - A form of this vitamin, the C ester has antioxidant and anti-inflammatory properties and has helped penetrate skin and prevent the return of acne. It is being tested for repairing damage to scar tissue from teen years.

Photodynamic therapy (PDT) with use of topical 5-aminolevulinic acid (ALA, Levulan Kerastick, Dusa Pharmaceuticals, Inc, Wilmington, MA) photosensitizing agent is a new modality for the treatment of acne Eighteen patients (aged 15 to 63) with moderate to severe inflammatory acne received ALA-PDT ALA remained in contact with skin for 15 to 30 minutes before exposure to blue light (ClearLight [Lumenis] or BLU-U [Dusa Pharmaceuticals, Inc]) or the Aurora DSR (Syneron Medical Ltd), which uses Electro-Optical Synergy (ELOS), a unique combination of optical and radiofrequency (RF) energy Patients received two to four ALA-PDT treatments over four to eight weeks or two cycles of ALA-PDT (weeks 2, 4) preceded by salicylic acid peel (weeks 1, 3) over four weeks The average follow-up time was four months On a scale of 00 to 40, the average acne grade improvement was 175

Another more traditional method for treating acne scarring is dermabrasion, which uses a rotating wire brush or spinning diamond instrument to wear down the surface of the skin As the skin heals, a new, smoother layer replaces the abraded skin It may take a bit longer for skin to heal using dermabrasion - usually between 10 days and 3 weeks

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